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Cannabinoid Deep Dive, Issue No. 2: CBG – “The Mother of All Cannabinoids”

The Endocannabinoid System

Cannabinoid Deep Dive, Issue No. 2: CBG – “The Mother of All Cannabinoids”

Jun 2, 20253 min read

Welcome back to Cannabinoid Deep Dive — our series where we explore the many faces of cannabis beyond just THC and CBD. In each issue, we unpack a different cannabinoid, explain how it works with your body, and explore why it matters for your health and wellness.

Today, we’re talking about CBG (cannabigerol) — often called the Mother of All Cannabinoids. Why? Because without it, you wouldn’t have THC, CBD, or a lot of the other cannabinoids we’re just beginning to understand.


What Is CBG?

CBG might not be as well-known as THC or CBD, but it plays a starring role behind the scenes. It starts as CBGA (cannabigerolic acid), which is the very first cannabinoid acid formed in the cannabis plant. From there, enzymes help convert it into other major cannabinoids like THCA, CBDA, and CBCA. When these acidic compounds are heated, they become the active forms we know as THC, CBD, and CBG.

So while CBG is usually found in small amounts in most strains, it’s absolutely essential. Some modern growers are even breeding cannabis strains specifically to retain more CBG by slowing down that natural conversion process.


Why We’re Just Learning About It Now

You might be wondering: if CBG was discovered back in 1964 (by none other than Dr. Raphael Mechoulam), why are we only hearing about it now? Simple: cannabis was labeled a Schedule 1 drug in 1970, right alongside heroin and LSD. That classification made it nearly impossible to study.

Before that, the Marihuana Tax Act of 1937 had already thrown a wrench in the works, and even the cannabis used in federally approved research wasn’t representative of what people were actually consuming. It wasn’t until states began creating their own medical and recreational programs that researchers could really dig in and start studying cannabis properly.


What CBG Might Help With

CBG is non-psychoactive, meaning it won’t get you high. But what it might do is pretty impressive. Early research shows CBG has anti-inflammatory properties that could help with arthritis, IBD, and chronic pain. It may also have neuroprotective effects, potentially benefiting conditions like Parkinson’s, Alzheimer’s, and Huntington’s.

It’s also being studied for its ability to reduce intraocular pressure (great news for glaucoma sufferers), stimulate appetite, and offer anxiety and depression relief without the side effects of pharmaceuticals.

CBG has shown antibacterial power, too — especially against tough-to-kill bugs like MRSA. It might even help with skin issues like eczema, acne, and psoriasis, thanks to its ability to calm inflammation and fight bacteria.

And while it’s still early, there’s growing curiosity around CBG’s potential role in cancer treatment, especially in relation to how it might affect cell growth.


Looking Ahead

CBG may be present in tiny amounts in most cannabis strains, but its potential is anything but small. As modern science catches up to ancient wisdom, cannabinoids like CBG are starting to take the spotlight.

With more research, better access, and smarter cultivation, we’re finally starting to unlock what this plant can really do. And CBG? It just might be leading the charge.

In the next issue, we’ll take a closer look at CBN — “The Sleepy One.” Stay tuned!

Article written by:

David Yrigoyen

David Yrigoyen

More about David
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@Tortillaschiwas is currently in its soft opening at 914 N. Grande Ave. in Barrio Hollywood, inside the former Grande Tortilla Factory.

Phoenix restaurateurs Armando Hernandez and chef Nadia Holguin, a James Beard-nominated duo originally from Chihuahua, Mexico, are behind the restaurant.

Tortillas Chiwas is currently open Thursdays through Saturdays from 5–10 pm with 38 seats. Reservations are available on OpenTable.

Photos by @tortillaschiwas 
Read @jackie_tran_’s article on Tucsonfoodie.com

#tucsonfoodie #tucsonnews@Tortillaschiwas is currently in its soft opening at 914 N. Grande Ave. in Barrio Hollywood, inside the former Grande Tortilla Factory. Phoenix restaurateurs Armando Hernandez and chef Nadia Holguin, a James Beard-nominated duo originally from Chihuahua, Mexico, are behind the restaurant. Tortillas Chiwas is currently open Thursdays through Saturdays from 5–10 pm with 38 seats. Reservations are available on OpenTable. Photos by @tortillaschiwas Read @jackie_tran_’s article on Tucsonfoodie.com #tucsonfoodie #tucsonnews
After 4pm, @Talegacoffee at 177 N. Church Ave. transforms into @_Velvetcowboy, serving cocktails, tapas, and late-night bar energy. Velvet Cowboy’s grand opening is Oct. 16, with upcoming events including drag brunches, DJs, and live music.🪩

This weekend’s hours are Saturday from 2pm to midnight and Sunday from noon to 10pm. Featured in this video is the Chilte(penis) martini special, made with chiltepin vodka, agua de chiltepin, and pickle juice, available until they sell out.🍸

“Opening this place feels a little surreal. To now have a space where we can bring together coffee, food, art, booze, and all the weird things we love feels like a reflection of how far we’ve come.” —Tyler Melo 

Read @jackie_tran_’s article on Tucsonfoodie.com

#tucsonnewsAfter 4pm, @Talegacoffee at 177 N. Church Ave. transforms into @_Velvetcowboy, serving cocktails, tapas, and late-night bar energy. Velvet Cowboy’s grand opening is Oct. 16, with upcoming events including drag brunches, DJs, and live music.🪩 This weekend’s hours are Saturday from 2pm to midnight and Sunday from noon to 10pm. Featured in this video is the Chilte(penis) martini special, made with chiltepin vodka, agua de chiltepin, and pickle juice, available until they sell out.🍸 “Opening this place feels a little surreal. To now have a space where we can bring together coffee, food, art, booze, and all the weird things we love feels like a reflection of how far we’ve come.” —Tyler Melo Read @jackie_tran_’s article on Tucsonfoodie.com #tucsonnews
@Tucsondoobie’s infused dinner series returns Sunday, Sept. 20, with chefs @chefmattlove and @chefroselena!🌿

The five-course dinner features playful takes on familiar favorites, including carne asada frites, a Sonoran hot dog-inspired tarte tatin, and a Gansito-inspired chocolate dessert.

The dinner runs from 6–9 pm near downtown Tucson. Tickets include the five-course meal, mocktails, sponsor experiences, a gift bag, and @tucsonprimeleaf product samples.

🎟️ Doobie members: $110
🎟️ Non-members: $150

The exact location will be emailed to ticket holders before the event. Membership is available during checkout.

🔗 in bio

MENU

COURSE 1 / AMUSE-BOUCHE 
*“Yu-Tang Crab Ain’t Nuthin To F*** Wit!*
-Goat/C.R.E.A.M. Cheese Crab Rangoons
-Taki Powder
-“Yu-Tang” Sauce (Yuzu Sweet & Sour)
-Orange Ash
-Green Onion Curls

COURSE 2 / APPETIZER 
*Purple Haze Carne Asada Frites*
-Smoked Coffee Guallijo Tri-Tip
-Melted Oaxaca
-Savory Avocado Mousse
-Purple Potato Shoestring Frites
-Heirloom Tomatoes
-Pickled Onion Powder

COURSE 3 / PALATE CLEANSER
*Agua-CHILL-e Slushie”* 
-Cucumber Serrano Granita
-Caramelized Chamoy Bowl
-Tajin
-Infused Mint/Basil Oil

COURSE 4 / MAIN ENTREE 
*Sonoran Dog(ish) Tarte Tatin*
-Beef Franks
-Mexican Coke Glazed Bacon
-Carmelized Shallots
-Refried Beans
-“Bolilo Style” Tarte Crust
-Jalapeño Mustard Crema
-Cherry Tomatoes
-Smoked Chile Guero

COURSE 5 / DESSERT
*Gansito à la Mode*
-Chocolate-glazed gâteau,
-Strawberry confit,
-Toasted marshmallow mousse,
-Mexican vanilla semifreddo
-Chocolate crisp.

Photo by @dalton.voss 
#tucsonlocal #tucsonevents@Tucsondoobie’s infused dinner series returns Sunday, Sept. 20, with chefs @chefmattlove and @chefroselena!🌿 The five-course dinner features playful takes on familiar favorites, including carne asada frites, a Sonoran hot dog-inspired tarte tatin, and a Gansito-inspired chocolate dessert. The dinner runs from 6–9 pm near downtown Tucson. Tickets include the five-course meal, mocktails, sponsor experiences, a gift bag, and @tucsonprimeleaf product samples. 🎟️ Doobie members: $110 🎟️ Non-members: $150 The exact location will be emailed to ticket holders before the event. Membership is available during checkout. 🔗 in bio MENU COURSE 1 / AMUSE-BOUCHE *“Yu-Tang Crab Ain’t Nuthin To F*** Wit!* -Goat/C.R.E.A.M. Cheese Crab Rangoons -Taki Powder -“Yu-Tang” Sauce (Yuzu Sweet & Sour) -Orange Ash -Green Onion Curls COURSE 2 / APPETIZER *Purple Haze Carne Asada Frites* -Smoked Coffee Guallijo Tri-Tip -Melted Oaxaca -Savory Avocado Mousse -Purple Potato Shoestring Frites -Heirloom Tomatoes -Pickled Onion Powder COURSE 3 / PALATE CLEANSER *Agua-CHILL-e Slushie”* -Cucumber Serrano Granita -Caramelized Chamoy Bowl -Tajin -Infused Mint/Basil Oil COURSE 4 / MAIN ENTREE *Sonoran Dog(ish) Tarte Tatin* -Beef Franks -Mexican Coke Glazed Bacon -Carmelized Shallots -Refried Beans -“Bolilo Style” Tarte Crust -Jalapeño Mustard Crema -Cherry Tomatoes -Smoked Chile Guero COURSE 5 / DESSERT *Gansito à la Mode* -Chocolate-glazed gâteau, -Strawberry confit, -Toasted marshmallow mousse, -Mexican vanilla semifreddo -Chocolate crisp. Photo by @dalton.voss #tucsonlocal #tucsonevents
@Talegacoffee at 177 N. Church Ave. transforms into @_Velvetcowboy after 4 pm, bringing cocktails, tapas, disco lights, and a lively bar atmosphere to the same space. The dual concept comes from the team behind Talega Coffee Co., with coffee and scratch-made breakfast and lunch served during the day, followed by happy hour and bar service at night.

Velvet Cowboy’s grand opening is Oct. 16, with upcoming events including drag brunches, DJs, and live music.🪩 

“Opening this place feels a little surreal. To now have a space where we can bring together coffee, food, art, booze, and all the weird things we love feels like a reflection of how far we’ve come.” —Tyler Melo 

Photos courtesy of @_velvetcowboy 
Read @jackie_tran_’s article on Tucsonfoodie.com

#tucsonnews@Talegacoffee at 177 N. Church Ave. transforms into @_Velvetcowboy after 4 pm, bringing cocktails, tapas, disco lights, and a lively bar atmosphere to the same space. The dual concept comes from the team behind Talega Coffee Co., with coffee and scratch-made breakfast and lunch served during the day, followed by happy hour and bar service at night. Velvet Cowboy’s grand opening is Oct. 16, with upcoming events including drag brunches, DJs, and live music.🪩 “Opening this place feels a little surreal. To now have a space where we can bring together coffee, food, art, booze, and all the weird things we love feels like a reflection of how far we’ve come.” —Tyler Melo Photos courtesy of @_velvetcowboy Read @jackie_tran_’s article on Tucsonfoodie.com #tucsonnews